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Clinical research in practice: Aguide for the bedside scientist. The next step is apical extension andmobilization of the pouch by sharp dissection using a Modified Orban Knife(Hu-Friedy, Chicago, IL) (Figure 9.6f and g).

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Sakaguchi K, Herrera JE, Saito S, Miki T, Bustin M, Vassilev A, Anderson CW, Appella E(1998) DNA damage activates p53 through a phosphorylation-acetylation cascade. As a resultof the ultimate breakdown of the plasma membrane, thecytoplasmic contents, including lysosomal enzymes, arereleased into the extracellular space.

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Thecumulative incidence of unprovoked seizures at 7 yearswas nearly 8%. A nurse examined the subjects on days three and eightafter the onset of infection.
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