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TZDs are insulin-sensitizing drugsthat act via the nuclear PPAR? to change activation of a plethora ofgenes and the levels of various expressed proteins. The hyperosmolarity of the in-terstitium is directly related to the transport activity ofthecells in this nephron segment. All of the studieshave been performed in animals.

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Any substance causing genetic mutation.Mutagenesis. Myopathy is morecommon when nicotinic acid/gemfibrozil orCYP3A4 inhibitor—ketoconazole/ erythromycin/cyclosporine/HIV protease inhibitor is givenconcurrently

Myopathy is morecommon when nicotinic acid/gemfibrozil orCYP3A4 inhibitor—ketoconazole/ erythromycin/cyclosporine/HIV protease inhibitor is givenconcurrently. (1988) Night to night vari-ability in sleep apnea and sleep related periodic leg movementsin the elderly. The target concentrations are achieved faster with less adversedrug effects [46]

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Vaughan CA, Singh S, Windle B, Sankala HM, Graves PR, Andrew Yeudall W, Deb SP, DebS (2011) p53 mutants induce transcription of NF-kappaB2 in H1299 cells through CBP andSTAT binding on the NF-kappaB2 promoter and gain of function activity.

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